What type of lymphoid stem cells differentiate in the bone marrow?

B cells are the type of lymphoid stem cells that differentiate in the bone marrow. In the process of hematopoiesis, which is the formation of blood cells, lymphoid progenitor cells that originate from hematopoietic stem cells in the bone marrow can develop into various types of lymphocytes.

B cells undergo their maturation fully in the bone marrow, where they differentiate and develop specific receptors for antigens. Once they mature, they leave the bone marrow and move to peripheral lymphoid tissues, like the spleen and lymph nodes, where they can be activated by their specific antigens.

In contrast, T cells originate from lymphoid progenitor cells as well, but they migrate to the thymus for maturation. NK cells, or natural killer cells, also arise from lymphoid progenitors, but their development differs from that of B and T cells and does not primarily occur in the bone marrow. Macrophages originate from monocytes, which are derived from myeloid progenitor cells and are generally associated with bone marrow but do not specify as lymphoid stem cells.

Thus, the correct identification of B cells as the lymphoid cells differentiating in the bone marrow highlights the location-specific aspect of lymphocyte development and the differing pathways of