How can cell-mediated immunity be transferred to a person with a normal immune system?

Cell-mediated immunity involves the activation of T cells and does not rely on antibodies, making the transfer of immunity significantly different from humoral immunity. When considering how to transfer cell-mediated immunity specifically to a person with a normal immune system, the transfer involves lymphoid cells, particularly T lymphocytes.

Transferring lymphoid cells from a hypersensitive person allows the recipient's immune system to gain specialized T cells, which can recognize and respond to specific antigens that were previously experienced by the donor. This process effectively transfers cell-mediated immune responses, enabling the recipient's immune system to better fight off infections or diseases that the donor could respond to due to prior sensitization.

Vaccination primarily works through the induction of an immune response in the host to generate memory cells, not through the direct transfer of cell-mediated immunity from one individual to another. Administering antibodies pertains to humoral immunity, providing immediate but temporary protection rather than activating cell-mediated responses. Blood transfusion can introduce a variety of immune components, but typically does not confer specific cell-mediated immunity in the way that the transfer of lymphoid cells would.