Which infection is commonly associated with DiGeorge syndrome due to impaired T-cell function?

DiGeorge syndrome is characterized by a genetic abnormality that results in thymic hypoplasia or aplasia, leading to impaired development of T-cells. This deficiency in T-cell function significantly compromises the immune response, making individuals with the condition particularly susceptible to certain infections.

Pneumocystis jirovecii pneumonia is an opportunistic infection commonly associated with severe immunodeficiency, primarily affecting individuals with low T-cell counts. In the context of DiGeorge syndrome, where T-cell function is impaired, patients are at increased risk for this specific infection.

The other infections listed, while they can affect immunocompromised individuals, are not as uniquely associated with T-cell deficiencies as Pneumocystis jirovecii pneumonia. For instance, infections like streptococcal and staphylococcal are better managed by other components of the immune system, such as B cells and phagocytic cells, rather than being specifically linked to T-cell function. Viral hepatitis is typically associated with a broader range of immune responses and does not exhibit the same high correlation with defects in T-cell function as Pneumocystis jirovecii pneumonia does in the context of DiGeorge syndrome.

Thus, the relationship between impaired T-cell function and